Speaking about how early setbacks molded her career, Keerthy made her hindi debut in the adaptation of the tamil classic Theri, Baby John. She was harshly stigmatized after her debut tamil film failed, with many filmmakers calling her "unlucky." The actress also had to deal with media speculations, as gossip columns were often making assumptions about her personal life, including false claims about her relationships with co-stars. She also discussed how she was frequently criticized for choosing a career path that deviated from others' expectations, such as declining offers or opportunities.
Keerthy gained support from her close friends, particularly samantha Ruth Prabhu, despite these difficulties. Throughout Keerthy's career, samantha, who portrayed the original character in Theri, was a consistent source of support. Their relationship, which was based on friendship and respect for one another, kept Keerthy centered despite the demands of the business.
Keerthy's initial hesitancy to take the part of savitri in mahanati was among the most unexpected disclosures from her talk. She was nervous when she was originally asked for the part and at first declined, thinking she wasn't prepared for such a difficult job. But Keerthy changed her mind and accepted the position, which ended up being a turning point in her career. In addition to winning her the coveted National Award for Best Actress, the movie significantly fulfilled her mother's wish to see her achieve success.