'Post-vaccination syndrome' (PVS) is a disorder where some people have persistent symptoms, even though COVID-19 vaccinations are normally safe. According to the New York Post, early research from Yale has shown unique immunological patterns in these people, which may lead to successful treatments.
 
"This research is still in its early stages, and we need to validate these findings," stated co-senior author Akiko Iwasaki, who is the Sterling professor of Immunobiology at Yale school of Medicine.
 
"However, this offers hope that we may eventually develop diagnostic tools and treatments for PVS."

Post-vaccination syndrome (PVS) symptoms
 
The symptoms of PVS include excessive weariness, exercise intolerance, brain fog, sleeplessness, and dizziness, according to Yale experts.  After immunization, these symptoms usually show up a day or two later and might get worse over time.
 
Harlan Krumholz, a professor of cardiology at Yale school of Medicine and co-senior author, stated, "It's evident that some people are having serious difficulties after vaccination."  "Our responsibility as scientists and clinicians is to listen, rigorously investigate, and find ways to help."

PVS is a true illness that has been reported after receiving a variety of vaccinations, including the COVID-19 vaccine, according to Dr. Marc Siegel, a clinical professor of medicine at NYU Langone Health.

Key Findings

Blood samples from 42 people who reported having PVS symptoms and 22 persons who did not were examined by researchers.
 
 Two kinds of white blood cells were found to be less prevalent in individuals who experienced symptoms.  Antibody levels against the SARS-CoV-2 spike protein were similarly lower among PVS participants who had never received COVID-19, most likely as a result of getting fewer doses of the vaccine.
 
"Fewer vaccine doses and no prior infection mean the immune system has had fewer opportunities to build a defense against the virus," scientists stated.

Elevated amounts of the SARS-CoV-2 spike protein, which contributes to the virus's capacity to infect cells, were also seen in certain PVS patients.  This has been connected in the past to a higher chance of long-term COVID-19.
 
 "We don't yet know if spike protein levels directly cause chronic symptoms, as some participants with PVS had no detectable spike protein," Iwasaki said.  "But it could be one contributing factor."
 
 According to the study, autoimmune, tissue injury, and Epstein-Barr virus (EBV) reactivation are other possible causes of PVS.
 
The Need for Further Research

Dr. Siegel emphasized Iwasaki's proficiency in immunology as well as her substantial studies on COVID-19 and vaccinations.  According to her research, a tiny proportion of vaccinated people who experience long-lasting adverse effects could have persisting spike protein and indications of immune system disturbance, he said.
 
 "This manifests as increased inflammatory immune cells (CD8 and TN alpha) and a reduction in CD4 helper cells, which aid in resolving inflammation and infection," Siegel said.
 
 Scholars concur that further research is required to enhance PVS diagnostic and therapy alternatives.
 
According to Krumholz, "We're only beginning to understand PVS,"  "Every medical intervention carries some risk, and it's important to acknowledge that vaccine-related adverse events can occur."
 
 "Our priority should be to approach these cases with rigorous science, compassion, and an open mind," he stated.
 
 Siegel reiterated this opinion, stressing the need for more studies to ascertain the prevalence of long-term vaccination adverse effects, how to anticipate them, and how to successfully treat them.
 

 

 
 

 
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SIBY JEYYA

26/02/2025 08:08 AM